Coadministration of ezetimibe with simvastatin
نویسندگان
چکیده
منابع مشابه
Efficacy and safety of coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia.
OBJECTIVES The study evaluated the efficacy and safety of long-term coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia (HeFH). BACKGROUND Aggressive intervention to achieve lipid goals for adolescents with HeFH is recommended to reduce risk of premature cardiovascular disease. METHODS In a multicenter, randomized, double-blind, place...
متن کاملSimvastatin with or without Ezetimibe in Familial Hypercholesterolemia To the Editor: In the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclero-
To the Editor: In the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) study by Kastelein et al. (April 3 issue),1 the addition of ezetimibe to simvastatin boosted the decrease in levels of low-density lipoprotein (LDL) cholesterol from 39.1% to 55.6%. However, the greater decrease in LDL cholesterol in the combined-therapy group did not affect pro...
متن کاملEzetimibe coadministered with simvastatin in patients with primary hypercholesterolemia.
OBJECTIVES The purpose of this study was to assess the efficacy and safety of ezetimibe administered with simvastatin in patients with primary hypercholesterolemia. BACKGROUND Despite the availability of statins, many patients do not achieve lipid targets. Combination therapy with lipid-lowering agents that act via a complementary pathway may allow additional patients to achieve recommended c...
متن کاملSimvastatin with or without ezetimibe in familial hypercholesterolemia.
BACKGROUND Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on the progression of atherosclerosis remains unknown. METHODS We conducted a double-blind, randomized, 24-month trial comparing the effects of daily therapy with 80 mg of simvastatin either with placebo or with ...
متن کاملIntensive lipid lowering with simvastatin and ezetimibe in aortic stenosis.
BACKGROUND Hyperlipidemia has been suggested as a risk factor for stenosis of the aortic valve, but lipid-lowering studies have had conflicting results. METHODS We conducted a randomized, double-blind trial involving 1873 patients with mild-to-moderate, asymptomatic aortic stenosis. The patients received either 40 mg of simvastatin plus 10 mg of ezetimibe or placebo daily. The primary outcome...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2003
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(03)81639-x